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For patients living with chronic heart failure, time is essential, so start with ENTRESTO (sacubitril/valsartan)1–3
Even when patients do not exhibit apparent symptoms, cardiac damage is constantly occurring4
ENTRESTO has a dual MoA that simultaneously inhibits vasoconstriction and promotes vasodilation5
Improve the chronic HFrEF patient’s experience vs ACEi (enalapril)7,10
National guidelines support ENTRESTO as a 1st line treatment option in chronic HFrEF1,2,15,16
ENTRESTO is indicated in adult patients for the treatment of symptomatic chronic heart failure with reduced ejection fraction.5
Please click here for safety information
ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor neprilysin inhibitor; HFrEF, heart failure with reduced ejection fraction; MoA, mode of action.
References:
- CaReMe UK HF algorithm. Available at: https://www.britishcardiovascularsociety.org/__data/assets/powerpoint_do.... (Accessed September 2021).
- Maddox TM, et al. J Am Coll Cardiol 2021;77(6):772–810.
- Ponikowski P, et al. ESC Heart Fail 2014;1(1):4–25.
- Mann DL, Bristow MR. Circulation 2005;111(21):2837–2849.
- ENTRESTO Summary of Product Characteristics. Electronic medicines compendium website, UK. Available at: https://www.medicines.org.uk/emc/product/7751/smpc. (Accessed September 2021).
- Claggett B, et al. N Engl J Med 2015;373(23):2289–2290.
- Lewis EF, et al. Circ Heart Fail 2017;10(8):e003430.
- McMurray JJ, et al. N Engl J Med 2014;371:993–1004.
- Solomon SD, et al. JACC Heart Fail 2016;4(10):816–822.
- Chandra A, et al. JAMA Cardiol 2018;3(6):498–505.
- Velazquez EJ, et al. N Engl J Med 2019;380(6):539–548.
- Desai AS, et al. JAMA 2019;322(11):1077–1084.
- Wachter R, et al. Eur J Heart Fail 2019;21(8):998–1007.
- Januzzi JL Jr, et al. JAMA 2019;322(11):1085–1095.
- Welsh HF Expert Reference Group 2021. HF in Wales in 2021 – a Parallel Approach.
- Heart Failure Hub Scotland guidelines. Available at: https://www.heartfailurehubscotland.co.uk/wp-content/uploads/2020/03/NHS.... (Accessed September 2021).