Prescribing information

 

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For patients living with chronic heart failure, time is essential, so start with ENTRESTO (sacubitril/valsartan)1–3

 

Icon of a person with a stethoscope, with text underneath 'for newly diagnosed chronic HFrEF patients'.

For newly diagnosed
chronic HFrEF patients...

 

 

Icon of a person with a medicine bottle, with text underneath 'and for previously diagnosed patients who are ACEi/ARB-naive'

...and for previously diagnosed
patients who are ACEi/ARB-naive

 

 

 Image of a heart with 'Even when patients do not exhibit apparent symptoms, cardiac damage is constantly occurring' - Burden of heart failure , text next to it.

Even when patients do not exhibit apparent symptoms, cardiac damage is constantly occurring4

 
 

Image of a heart with 'ENTRESTO has a dual MoA that simultaneously inhibits vasoconstriction and promotes vasodilation', text next to it - mode of action.

ENTRESTO has a dual MoA that simultaneously inhibits vasoconstriction and promotes vasodilation5

 
 

Image of a hospital with 'Change the disease trajectory in chronic HFrEF' text next to it - disease trajectory.

Change the disease trajectory in chronic HFrEF‌1,2,5–14

 
 

Image of a graph with 'Improve the chronic HFrEF patient’s experience vs ACEi (enalapril)' text next to it - Improvements in quality of life.

Improve the chronic HFrEF patient’s experience vs ACEi (enalapril)7,10

 
 

Image of a shield with 'National guidelines support ENTRESTO as a 1st line treatment option in chronic HFrEF' text next to it - guidelines.

National guidelines support ENTRESTO as a 1st line treatment option in chronic HFrEF1,2,15,16

 
 

 

ENTRESTO is indicated in adult patients for the treatment of symptomatic chronic heart failure with reduced ejection fraction.5

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ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor neprilysin inhibitor; HFrEF, heart failure with reduced ejection fraction; MoA, mode of action.

References:

  1. CaReMe UK HF algorithm. Available at: https://www.britishcardiovascularsociety.org/__data/assets/powerpoint_do.... (Accessed September 2021).
  2. Maddox TM, et al. J Am Coll Cardiol 2021;77(6):772–810.
  3. Ponikowski P, et al. ESC Heart Fail 2014;1(1):4–25.
  4. Mann DL, Bristow MR. Circulation 2005;111(21):2837–2849.
  5. ENTRESTO Summary of Product Characteristics. Electronic medicines compendium website, UK. Available at: https://www.medicines.org.uk/emc/product/7751/smpc. (Accessed September 2021).
  6. Claggett B, et al. N Engl J Med 2015;373(23):2289–2290.
  7. Lewis EF, et al. Circ Heart Fail 2017;10(8):e003430.
  8. McMurray JJ, et al. N Engl J Med 2014;371:993–1004.
  9. Solomon SD, et al. JACC Heart Fail 2016;4(10):816–822.
  10. Chandra A, et al. JAMA Cardiol 2018;3(6):498–505.
  11. Velazquez EJ, et al. N Engl J Med 2019;380(6):539–548.
  12. Desai AS, et al. JAMA 2019;322(11):1077–1084.
  13. Wachter R, et al. Eur J Heart Fail 2019;21(8):998–1007.
  14. Januzzi JL Jr, et al. JAMA 2019;322(11):1085–1095.
  15. Welsh HF Expert Reference Group 2021. HF in Wales in 2021 – a Parallel Approach.
  16. Heart Failure Hub Scotland guidelines. Available at: https://www.heartfailurehubscotland.co.uk/wp-content/uploads/2020/03/NHS.... (Accessed September 2021).
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UK | October 2021 | 145880
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Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse events should also be reported to Novartis via [email protected] or online through the pharmacovigilance intake (PVI) tool at www.report.novartis.com
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