1. Medicines
  2. Cardio-Metabolic
  3. ENTRESTO® (sacubitril/valsartan)
  4. Mode of action

Prescribing information

 

Mode of action

   

Prescribe ENTRESTO® to act directly on the heart and improve cardiac function1

Watch the mechanism of action video below to gain a deeper understanding of ENTRESTO’s complementary actions2

 

Discover how ENTRESTO can improve the heart’s structure and function, and reverse cardiac remodelling vs ACEi/ARBs1,3,4

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ENTRESTO is indicated in adult patients for the treatment of symptomatic chronic heart failure with reduced ejection fraction.2

Please click here for safety information

ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor neprilysin inhibitor; RAAS, renin-angiotensin-aldosterone system.

References:

  1. Januzzi JL Jr, et al. JAMA 2019;322(11):1085–1095.
  2. ENTRESTO Summary of Product Characteristics. Electronic medicines compendium website, UK. Available at: https://www.medicines.org.uk/emc/product/7751/smpc. (Accessed September 2021).
  3. Desai AS, et al. JAMA 2019;322(11):1077–1084.
  4. Wang Y, et al. J Am Heart Assoc 2019;8(13):e012272.
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UK | October 2021 | 145884
Cardio-metabolic
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Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse events should also be reported to Novartis via [email protected] or online through the pharmacovigilance intake (PVI) tool at www.report.novartis.com
If you have a question about the product, please contact Medical Information on 01276 698370 or by email at [email protected]