Cosentyx is indicated alone or in combination with methotrexate, for the treatment of active PsA in adult patients when the response to previous DMARDs has been inadequate; for the treatment of active AS in adults who have responded inadequately to conventional therapy; and for the treatment of active nr-axSpA, with objective signs of inflammation, as indicated by elevated C-reactive protein and/or MRI evidence, in adults who have responded inadequately to NSAIDs.
Fast and lasting efficacy2–4
Did you know?
Registry data show that the majority of biologic-initated PsA patients present with 3+ manifestations (n=354)6
Cosentyx has demonstrated fast and lasting efficacy in all 6 key PsA manifestations*1,3–5,7,8
Cosentyx is recommended by EULAR* and NICE for use in PsA as a first-line biologic after DMARD failure9,10
Dive into the data below to see how Cosentyx can help your PsA patients LOOK, MOVE and FEEL better
Don't miss EXCEED
The first head-to-head trial with a specific rheumatology primary endpoint to evaluate the efficacy and safety of Cosentyx vs adalimumab in patients with active PsA.11
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*Recommendation 6: In patients with peripheral arthritis and an inadequate response to at least one csDMARD, therapy with a bDMARD should be commenced; when there is relevant skin involvement, an IL-17 inhibitor or IL-12/23 inhibitor may be preferred.9
†Cosentyx 150 mg group includes placebo-switchers and patients who escalated to 300 mg starting at week 128 or later, after a protocol amendment.8
‡The primary endpoint of the FUTURE 2 study was ACR20 response at Week 24 and was met (Cosentyx 300 mg: 54%, Cosentyx 150 mg: 51%, placebo: 15%; P<0.0001 for both).1§As observed in patients (94 with Cosentyx 150 mg) with this symptom at baseline.1
¶As observed in patients (40 with Cosentyx 150 mg) with this symptom at baseline.1
¥The primary endpoint of the TRANSFIGURE study was percentage change in total fingernail NAPSI score from baseline to week 16 and was met (Cosentyx 300 mg: -45.3%, placebo: -10.8%; P<0.001).3
€The primary endpoint of the MAXIMISE study was met. ASAS20 response at Week 12: Cosentyx 300 mg 63%, placebo 31%; P<0.001 (multiple imputation).5
ACR, American College of Rheumatology; AS, ankylosing spondylitis; ASAS, Assessment in SpondyloArthritis international Society; axSpA, axial spondyloarthritis; DMARD, disease-modifying antirheumatic drug; EULAR, European League Against Rheumatism; GRAPPA, Group for Research and Assessment of Psoriasis and Psoriatic Arthritis; IL, interleukin; NAPSI, Nail Psoriasis Severity Index; NSAID, non-steroidal anti-inflammatory drug; nr-axSpA, non-radiographic axial spondyloarthritis; PASI, Psoriasis Area and Severity Index; PsA, psoriatic arthritis; PsO, plaque psoriasis; s.c., subcutaneous.
- McInnes IB et al. Lancet. 2015;386:1137–46.
- Deodhar A et al. Arthritis Rheumatol. 2020 (epub ahead of print).
- Reich K et al. Br J Dermatol. 2019;181:954–66.
- Thaci D et al. J Am Acad Dermatol. 2015;73:400–9.
- Baraliakos X et al. Ann Rheum Dis. 2019;78. Abstract OP0235.
- Ogdie A et al. Arthritis Rheumatol. 2019; 71 (suppl. 10). Abstract 2475.
- Leung YY et al. Front Med (Lausanne). 2018;5:246.
- McInnes IB et al. Lancet Rheumatol. 2020;2:227–35.
- Gossec L et al. Ann Rheum Dis. 2020;79: 700–12.
- NICE guideline TA445. Available at: https://www.nice.org.uk/guidance/ta445/chapter/1-Recommendations (Accessed January 2021).
- McInnes IB et al. Lancet. 2020;395:1496–1505.
- Lee S et al. Pharmacy and Therapeutics. 2010;35:680–9.
- Reich K et al. Br J Dermatol. 2020 (ePub ahead of print).
- Feld J et al. Nat Rev Rheumatol. 2018;14:363–71.
- Gottlieb AB et al. J Dermatol Treat. 2006;17:343–52.
- Ritchlin CT et al. N Engl J Med. 2017;376:957–70.