1. Therapy Areas
  2. Rheumatology
  3. Non-radiographic axial spondyloarthritis (nr-axSpA)
  4. Disease burden

Disease burden

   

Axial spondyloarthritis (axSpA) places significant burden on patients across the spectrum of axSpA (non-radiographic axSpA [nr-axSpA] and ankylosing spondylitis [AS]).1

Patients with nr-axSpA may suffer from night-time back pain and morning stiffness, but don’t always tell their healthcare professional. This may be especially true in patients whose stiffness resolves with movement.2

Both nr-axSpA and AS have a similar symptom burden:1

Handrawn image of man icon displaying pain

Pain

Handrawn image of person icon displaying fatigue

Fatigue

Handrawn image of person icon displaying functional impairment

Functional impairment

Handrawn image of briefcase icon displaying lost work time

Lost work time

Handrawn image of person icon sitting on bed

Reduced activity

 

 

 

Similarities3

""

Clinical presentation

Level of pain

Decease in functional abilities

Decrease in HRQoL*

Patient global assessment of disease

Differences

""

Radiographic damage in AS3

Reduced spinal mobility in AS4

More women with nr-axSpA5

More men with AS (ratio 2:1 vs women)5

 

 

Image of blue arrow with link to Disease identification

 

*As measured by SF-36 and ASQoL questionnaires.3

AS, ankylosing spondylitis; ASQoL, Ankylosing Spondylitis Quality of Life; axSpA, axial spondyloarthritis; HRQoL, health-related quality of life; nr-axSpA, non-radiographic axial spondyloarthritis; SF-36, Short Form 36 Health Survey.

References:

  1. Mease PJ, et al. Arthritis Care Res (Hoboken). 2018;70(11):1661–1670.
  2. Strand V & Singh JA. Mayo Clin Proc. 2017;92(4):555–564.
  3. Kiltz U, et al. Arthritis Care Res (Hoboken). 2012;64(9):1415–1422.
  4. Malaviya AN, et al. Int J Rheum Dis. 2015;18(7):736–741.
  5. Boonen A, et al. Semin Arth Rheum. 2015;44(5):556–562.
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Gender differences

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