Axial spondyloarthritis (axSpA) places significant burden on patients across the spectrum of axSpA (non-radiographic axSpA [nr-axSpA] and ankylosing spondylitis [AS]).1

Patients with nr-axSpA may suffer from night-time back pain and morning stiffness, but don’t always tell their healthcare professional. This may be especially true in patients whose stiffness resolves with movement.2

Both nr-axSpA and AS have a similar symptom burden:1

Handrawn image of man icon displaying pain


Handrawn image of person icon displaying fatigue


Handrawn image of person icon displaying functional impairment

Functional impairment

Handrawn image of briefcase icon displaying lost work time

Lost work time

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Reduced activity






Clinical presentation

Level of pain

Decease in functional abilities

Decrease in HRQoL*

Patient global assessment of disease



Radiographic damage in AS3

Reduced spinal mobility in AS4

More women with nr-axSpA5

More men with AS (ratio 2:1 vs women)5



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*As measured by SF-36 and ASQoL questionnaires.3

AS, ankylosing spondylitis; ASQoL, Ankylosing Spondylitis Quality of Life; axSpA, axial spondyloarthritis; HRQoL, health-related quality of life; nr-axSpA, non-radiographic axial spondyloarthritis; SF-36, Short Form 36 Health Survey.


  1. Mease PJ, et al. Arthritis Care Res (Hoboken). 2018;70(11):1661–1670.
  2. Strand V & Singh JA. Mayo Clin Proc. 2017;92(4):555–564.
  3. Kiltz U, et al. Arthritis Care Res (Hoboken). 2012;64(9):1415–1422.
  4. Malaviya AN, et al. Int J Rheum Dis. 2015;18(7):736–741.
  5. Boonen A, et al. Semin Arth Rheum. 2015;44(5):556–562.
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UK | April 2021 | 114838

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