1. Therapy Areas
  2. Haematology
  4. Vaso-occlusion, VOCs and end-organ damage
  5. The burden of VOCs in sickle cell disease (SCD)

The burden of VOCs in sickle cell disease (SCD)

   

VOCs are a major burden of SCD1

One or more VOCs requiring a healthcare visit in a given year has been associated with an increased risk of death at an earlier age2

Survival in sickle cell anaemia (HbSS) by severe pain crises requiring an emergency department (ED) visit/hospitalisation in the past year:2

 

This analysis included 264 adult patients with HbSS followed for a median of ~5 years in the United States (The Bethesda Sickle Cell Cohort Study, 2001–2007)2

  • VOCs were defined as patient-reported ED visit or hospitalisation for pain treatment in the 12 months prior to enrollment2
  • VOCs were associated with death at a younger age: 66.2 years for patients with no VOCs in the past year and 55.8 years for patients with ≥1 VOCs in the past year (p=0.04)2

 

Abbreviations: ED, emergency department; HbSS, sickle cell anaemia; SCD, sickle cell disease; VOCs, vaso-occlusive crises.

References

  1. Conran N, et al. Hemoglobin. 2009;33(1):1–16.
  2. Darbari DS, et al. PLoS One. 2013;8(11):e79923. 
UK | April 2021 | 104284
Haematology
Article
×

Ask Speakers

×

Medical Information Request

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse events should also be reported to Novartis via [email protected] or online through the pharmacovigilance intake (PVI) tool at www.report.novartis.com
If you have a question about the product, please contact Medical Information on 01276 698370 or by email at [email protected]