VOCs are a major burden of SCD1
Vaso‑occlusion and VOCs can have a range of clinical complications1–4
Ongoing vaso‑occlusion and recurrent VOCs are associated with decreased quality of life, end-organ damage, multiorgan failure and death
Abbreviations: RBC, red blood cell; SCD, sickle cell disease; VOCs, vaso-occlusive crises.
References
- Conran N, et al. Hemoglobin. 2009;33(1):1–16.
- Rees DC, et al. Lancet. 2010;376(9757):2018–2031.
- Piel FB, et al. N Engl J Med. 2017;376(16):1561–1573.
- Puri L, et al. Paediatr Drugs. 2018;20(1):29–42.
- Saidkasimova S, et al. Eur J Ophthalmol. 2016;26(5):431–435.
- Liem RI, et al. Pediatr Blood Cancer. 2009;52(7):842–846.
- Sachdev V, et al. J Am Coll Cardiol. 2007;49(4):472–479.
- Nath KA, Hebbel RP. Nat Rev Nephrol. 2015;11(3):161–171.
- Crane GM, Bennet NE. Anemia. 2011;2011:297–364.
- Smith-Whitley K. Blood. 2014;124(24):3538–3542.
- Thust SC, et al. Br J Radiol. 2014;87:20130699.
- Vichinsky EP, et al. N Engl J Med. 2000;342(25):1855–1865.
- Gladwin MT, et al. N Engl J Med. 2004;350(9):886–895.
- Shah R, et al. World J Gastrointest Pathophysiol. 2017;8(3):108–116.
- Koskinas J, et al. Scand J Gastroenterol. 2007;42:499–507.
- Sanders WJ. BMC Hematol. 2018;18:5.