A UK subset of the worldwide, prospective, non-interventional AWARE (A World-wide Antihistamine-Refractory chronic urticaria patient Evaluation) study was conducted to provide data demonstrating the real-life burden of CU in the UK.1

The study assessed the treatment patterns, burden of disease and rates of healthcare resource utilisation in patients with CU who failed first-line H1 antihistamine treatment in the real-life clinical setting.1

The results of this UK subset of AWARE were published in Clinical and Experimental Dermatology in 2020.1


Study design1




Assessments made throughout the 2-year follow up at different visits:1

  • Drug therapy
  • Satisfaction with current therapy (VAS)
  • Symptoms: Angioedema and hives
  • Healthcare use
  • Autologous serum skin test
  • PROs: QoL (DLQI and EQ-5D), disease activity (UAS7) and work productivity impairment (WPAI)





UK data from AWARE revealed a high burden of disease in adult H1-AH (H1-antihistamine)-refractory patients with CU. CU impacted work productivity, activity, HR-QoL and contributed to high use of healthcare facilities.1

Compared with global data, UK patients were more likely to visit their GP, and were more likely to be lost to follow-up (72.1%).1




AWARE has been summarised in a handy guide for quick reference and understanding.




CU, chronic urticaria; CSU, chronic spontaneous urticaria; DLQI, Dermatology Quality of Life Index; EQ-5D, EuroQol five-dimensions instrument; GP, general practitioner; HRQoL, health-related quality of life; PROs, patient reported outcomes; QoL, quality of life; UAS7, 7-day Urticaria Activity Score; VAS, visual analogue scale; WPAI, work productivity and activity impairment.


  1. Savic S, et al. Clin Exp Dermatol 2020;45:1003–1010.
Rate this content: 
No votes yet
UK | October 2021 | 146364

Ask Speakers


Medical Information Request

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse events should also be reported to Novartis via [email protected] or online through the pharmacovigilance intake (PVI) tool at www.report.novartis.com
If you have a question about the product, please contact Medical Information on 01276 698370 or by email at [email protected]