Breast cancer is the most common type of cancer in the UK, accounting for 15% of all new cancer cases.1
There are different types of breast cancer. The disease can be categorised in a number of ways, such as by how far it has progressed and the molecular make-up of the tumour.
Advanced breast cancer includes cancers that have spread to the tissues around the breast (locally advanced) or to other parts of the body (metastatic).2,3
HR+/HER2− is a way of describing the molecular make-up of the cancer. Hormone receptor-positive (HR+) means that the cancer has receptors for the female hormones oestrogen and/or progesterone. Some breast cancers have too much of a protein called human epidermal growth factor receptor 2 (HER2), but HER2-negative (HER2−) means this is not the case.4
The type of breast cancer you have will determine your options for treatment.
HR+/HER2−, hormone receptor-positive/human epidermal growth factor 2-negative.
- Cancer Research UK. Available at: https://www.cancerresearchuk.org/health-professional/cancer-statistics/s... [Accessed March 2020].
- El Sayed R, et al. Front Oncol 2019;9:510.
- Cancer Research UK. 2017. Available at: https://about-cancer.cancerresearchuk.org/about-cancer/breast-cancer/sta... [Accessed March 2020].
- Macmillan Cancer Support. Available at: https://www.macmillan.org.uk/cancer-information-and-support/breast-cance... [Accessed March 2020].