Breast cancer is the most common type of cancer in the UK, accounting for 15% of all new cancer cases.1

There are different types of breast cancer. The disease can be categorised in a number of ways, such as by how far it has progressed and the molecular make-up of the tumour.

Advanced breast cancer includes cancers that have spread to the tissues around the breast (locally advanced) or to other parts of the body (metastatic).2,3

HR+/HER2− is a way of describing the molecular make-up of the cancer. Hormone receptor-positive (HR+) means that the cancer has receptors for the female hormones oestrogen and/or progesterone. Some breast cancers have too much of a protein called human epidermal growth factor receptor 2 (HER2), but HER2-negative (HER2−) means this is not the case.4

The type of breast cancer you have will determine your options for treatment.


HR+/HER2−, hormone receptor-positive/human epidermal growth factor 2-negative.


  1. Cancer Research UK. Available at: [Accessed March 2020].
  2. El Sayed R, et al. Front Oncol 2019;9:510.
  3. Cancer Research UK. 2017. Available at: [Accessed March 2020].
  4. Macmillan Cancer Support. Available at: [Accessed March 2020].
HCP20-C021 July 2020.

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