Information about LUCENTIS and its range of ophthalmic indications.
LUCENTIS is an anti-VEGF with a broad range of ophthalmic indications1
LUCENTIS is approved for the following indications1:
LUCENTIS specifically targets VEGF-A to inhibit neovascularisation1–3
VEGF-A plays a key role in the angiogenic cascade, leading to neovascularisation and increased permeability.4–12
LUCENTIS 0.5 mg is indicated in adults for:
- The treatment of neovascular (wet) age-related macular degeneration (AMD)
- The treatment of visual impairment due to diabetic macular oedema (DMO)
- The treatment of proliferative diabetic retinopathy (PDR)
- The treatment of visual impairment due to macular oedema secondary to retinal vein occlusion (branch RVO or central RVO)
- The treatment of visual impairment due to choroidal neovascularisation (CNV).
LUCENTIS 0.2 mg is indicated in preterm infants for:
- The treatment of retinopathy of prematurity (ROP) with zone I (stage 1+, 2+, 3 or 3+), zone II (stage 3+) or AP-ROP (aggressive posterior ROP) disease.
AMD, age-related macular degeneration; AP-ROP, aggressive posterior ROP; BRVO, branch retinal vein occlusion; CNV, choroidal neovascularisation; CRVO, central retinal vein occlusion; DMO, diabetic macular oedema; PDR, proliferative diabetic retinopathy; ROP, retinopathy of prematurity; RVO, retinal vein occlusion; VEGF, vascular endothelial growth factor.
- LUCENTIS® (ranibizumab) Summary of Product Characteristics, July 2020.
- Ferrara N et al. Retina 2006;26(8):859–870.
- Steinbrook R. N Engl J Med 2006;355(14):1409–1412.
- Aiello LP et al. N Engl J Med 1994;331(22):1480–1487.
- Campochiaro PA et al. Mol Vis 1999;5:34.
- Dvorak HF et al. Am J Pathol 1995;146(5):1029–1039.
- Miller JW. Am J Pathol 1997;151(1):13–23.
- Miller JW et al. Am J Pathol 1994;145(3):574–584.
- Pe’er J et al. Lab Invest 1995;72(6):638–645.
- Spilsbury K et al. Am J Pathol 2000;157(1):135–144.
- Kurihara T et al. eLife 2016;5:e14319.
- Arden GB et al. Curr Diabetes Rev 2011;7(5):291–304.