Prescribing information



Entresto is associated with reverse cardiac remodelling and improvement in cardiac function1,2

Icon for the PROVE-HF study

Dr James Januzzi, Principal Investigator of PROVE-HF, summarises the PROVE-HF study and gives a real-world example of a patient in his clinic.





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Read the EVALUATE-HF study paper

Read the PROVE-HF study paper


There’s a wealth of data supporting the use of Entresto in your chronic HFrEF patients1–7

Graphic showing Clinical evidence: PARADIGM-HF, PIONEER-HF, TRANSITION, PROVE-HF, EVALUATE-HFParadigm-hf3  Pioneer-hf4  Transition5,6  Prove-hf1  Evaluate-hf2 


Indication: Entresto is indicated in adult patients for treatment of symptomatic chronic heart failure with reduced ejection fraction.7

HFrEF, heart failure with reduced ejection fraction.


  1. Januzzi JL Jr et al. JAMA 2019; 322:1085–1095.
  2. Desai AS et al. JAMA 2019; 322:1077–1084.
  3. McMurray JJV et al. N Engl J Med 2014; 371:993–1004.
  4. Velazquez EJ et al. N Engl J Med 2019; 380:539–548.
  5. Wachter R et al. Eur J Heart Fail 2019; 21:998–1007.
  6. Pascual-Figal D et al. ESC Heart Fail 2018; 5:327–336.
  7. Entresto Summary of Product Characteristics, 2020.
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ENT20-C046e(1) July 2020.

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