Prescribing information



There’s a wealth of data supporting the use of Entresto in your
chronic HFrEF patients1–7

Make Entresto your first choice, wherever your patients are in their chronic HFrEF journey1–7

 Paradigm-hf1  Pioneer-hf2  Transition3,4  Prove-hf5  Evaluate-hf6


Indication: Entresto is indicated in adult patients for treatment of symptomatic chronic heart failure with reduced ejection fraction.7

HFrEF, heart failure with reduced ejection fraction.


  1. McMurray JJV et al. N Engl J Med 2014; 371:993–1004.
  2. Velazquez EJ et al. N Engl J Med 2019; 380:539–548.
  3. Pascual-Figal D et al. ESC Heart Fail 2018; 5:327–336.
  4. Wachter R et al. Eur J Heart Fail 2019; 21:998–1007.
  5. Januzzi JL Jr et al. JAMA 2019; 322:1085–1095 plus supplementary info.
  6. Desai AS et al. JAMA 2019; 322:1077–1084 plus supplementary info.
  7. Entresto Summary of Product Characteristics, 2020.
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ENT20-C046b(1) July 2020.

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Adverse events should be reported. Reporting forms and information can be found at Adverse events should also be reported to Novartis via [email protected] or online through the pharmacovigilance intake (PVI) tool at
If you have a question about the product, please contact Medical Information on 01276 698370 or by email at [email protected]